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Pepcid Liquid Adverse Reactions and Side Effects. Talk with the doctor In general, you can take over-the-counter (OTC) famotidine (Pepcid AC, Zantac 360) at any time of the day or night to help treat heartburn symptoms. Pepcid AC ( famotidine ) is an over-the-counter (OTC) drug used to prevent or relieve heartburn associated with acid indigestion and sour stomach (caused by consuming particular food and drinks). It is used to treat several conditions related to the esophagus, stomach, and intestines. These ingredients have been for years helping millions of patients to relieve heartburn effectively and safely. Although they work more slowly than antacids they provide relief for a longer period of time. 50% of reviewers reported a positive effect, while 50% reported a negative effect PEPCID AC® provides heartburn relief that starts working in minutes, and controls acid all day or all night ,* but it can even prevent heartburn if taken 15 to 60 minutes before a meal. 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Pepcid Complete is an over the counter acid reflux medicine, combining two proven active ingredients in one drug – antacids (magnesium hydroxide and calcium carbonate)and acid reducer (famotidine). But it was such a long time I ago I don’t know if she was just referring to Tums. Learn about the PEPCID ® money back guarantee and find the details about our policy here. It may be given to you for other reasons. From the #1 doctor recommended acid reducer brand, PEPCID COMPLETE ® is a chewable tablet that provides dual action heartburn relief that works fast and lasts. Prescription-strength Pepcid tablets are made by Merck and Company, and prescription Pepcid liquid (oral suspension) is made by Salix Pharmaceuticals. I remember a doctor in the past at clinic telling me I could take over the counter acid reflux meds while on my prescription. Before taking this medication, patients should discuss any other drugs they are taking with their doctor or pharmacist. 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