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It has been written by french prescribers and patient experts, drawing on nearly a decade of experience. It’s not fully understood how it works, but it seems to block nerve signals from the spinal cord. Doses of baclofen are generally initiated around 5 mg per dose, up to three times daily. Do not drive or operate machinery, or perform hazardous tasks if baclofen makes you drowsy, dizzy, or sleepy Average daily dose for patients under 12 years was 274 mcg/day, with a range of 24 mcg/day to 1,199 mcg/day. The disease can be acute, sometimes almost instantly. Does Baclofen Need Prescription. These recommendations are intended to help you prescribe baclofen in full confidence that you will find, as we have, that this treatment is superior to all others. Dosage requirement for pediatric patients over 12 years does not seem to be different from that of adult patients. 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