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It may be given to you for other reasons. This leads to less unpleasant GERD symptoms. 6 out of 10 from a total of 6 ratings on Drugs. Famotidine has been available on prescription since 1987 in the UK, for treating peptic ulcer and related diseases Find 21 user ratings and reviews for Pepcid AC Oral on WebMD including side effects and drug I get bad heartburn and this is the best over the counter medication. 50% of reviewers reported a positive effect, while 50% reported a negative effect PEPCID AC® provides heartburn relief that starts working in minutes, and controls acid all day or all night ,* but it can even prevent heartburn if taken 15 to 60 minutes before a meal. Comments sorted by Best Top New Controversial Q&A Add a Comment.. In general, you can take over-the-counter (OTC) famotidine (Pepcid AC, Zantac 360) at any time of the day or night to help treat heartburn symptoms. 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