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They take about 1 hour to start working effectively. Studies have shown it is best to take OTC famotidine 1 hour before an evening meal to help prevent heartburn and indigestion in the evening and during bedtime which may interfere with your sleep Generally all are the same. OTC famotidine is available as a tablet, chewable tablet, or capsule. Pepcid products are widely available over the counter at pharmacies. If your vet has recommended a famotidine product for your pet, a good starting point is Pepcid 20mg. Good for you for being a wise consumer shopper! Doses of prescription Pepcid depend on the condition being treated. What is the difference between Pepcid and over-the-counter famotidine? Read on to learn more about this shortage and what to do if you are taking this zetia 10mg price drug Although they work more slowly than antacids they provide relief for a longer period of time. These drugs effectively treat about ½ the patients with GERD. Famotidine is a prescription and over the counter drug used to treat ulcers of the stomach and intestines and to prevent intestinal ulcers from coming back after they have healed. The over the counter PPI’s are Tagamet HB, Pepcid AC, Axid, and Zantac. Over-the-counter famotidine (Pepcid AC) is used to treat heartburn, and prescription famotidine (Pepcid) treats heartburn as well as stomach ulcers and gastroesophageal reflux disease (GERD). Is Prevacid still available by presciption? Jane Top Reply Quote Post Reply. Alot of people including myself, the prescription for Prilosec is cheaper than OTC but yes, same ingredients, same dose. A headache is the most common side more Prescription only. Prevacid is available in prescription and over-the-counter (OTC) versions In general, you can take over-the-counter (OTC) famotidine (Pepcid AC, Zantac 360) at any time of the day or night to help treat heartburn symptoms.